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PASTE: Probabilistic Alignment of Spatial Transcriptomics Experiments

PASTE is a computational method that leverages both gene expression similarity and spatial distances between spots to align and integrate spatial transcriptomics data. In particular, PASTE provides two main functionalities:

  1. Pairwise Alignment: align spots across pairwise slices.

  2. Center Alignment: integrate multiple slices into one center slice.

PASTE Overview Figure

Manuscript

You can view our preprint on bioRxiv.